ESI/MS study on sulfur containing ß-lactams and their interactions with glutathione

MEDI 281

Maya Kostova, Carey J. Myers, cm3158a@american.edu, and Monika Konaklieva. Department of Chemistry, American University, 4400 Massachusetts Ave NW, Washington, DC 20016
Glutathione is a small intracellular protein that functions as a free radical scavenger, amino acid transporter and cell life cycle regulator. It also plays a role in the body's antioxidant defense system and in drug detoxification. Glutathione is mostly present in the cell in its reduced form. As a thiol, it is likely to form disulfide bonds with other thiol compounds. This study examines the interactions of several sulfur-containing ß-lactams with glutathione using ESI/MS. The experimental results of this preliminary study assisted in broadening our knowledge of ß-lactam-glutathione interactions.
 

Poster Session
7:00 PM-9:00 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Medicinal Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007