A silane coupling agent approach for attaching PEG or biotin to the surface of magnetic nanoparticles

INOR 270

Jacqueline A. Nikles, Department of Chemistry, University of Alabama at Birmingham, 901 S 14th St, Birmingham, AL 35294 and David E Nikles, dnikles@mint.ua.edu, Department of Chemistry and Center for Materials for Information Technology, The University of Alabama, Box 870209, Tuscaloosa, AL 35487-0209.
Our interest in dispersing magnetic nanoparticles in aqueous buffers has led us to synthesize new ligands based on silane coupling agents. Triethoxy-(3-isocyanatopropyl)silane was reacted with triethylene glycol monomethyl ether to give the corresponding urethane. (3-aminopropyl)triethoxysilane was reacted with activated biotin to give the corresponding amide. The two ligands were attached to the surface of magnetic nanoparticles (either magnetite, Fe or FePt) by silane coupling agent chemistry.
 

Nanoscience: Applications
7:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Inorganic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007