Quantitative raman analysis based on hole-enhanced raman scattering

ANYL 229

Hao Chen, hchen@anl.gov1, John Bahns2, Rong Wang, wangr@iit.edu1, and Liaohai Chen2. (1) Department of Biological, Chemical and Physical Sciences, Illinois Institute of Technology, Life Sciences Building, 3101 Dearborn St., Chicago, IL 60616, (2) Argonne National Laboratory
We reported Stokes and anti-Stokes non-resonant Hole-Enhanced Raman Scattering (HERS) spectra with high signal to noise ratio (S/N) for the first time for R6G molecules and other biomolecules adsorbed onto random nanoholes in thin gold films. Compared to conventional Surface Enhanced Raman Scattering from nanometric gold colloid particles, HERS exhibits higher strength gain; exceptional reproducibility, simple and reliable substrate preparation and excellent mechanical stability. In addition, we specifically anchored biological molecules within the individual holes via surface conjugation, and topographically dependent HERS spectra were probed. Providing a Raman substrate with uniform “hot spots”, we expect that HERS will make the quantitative Raman detection of biology molecules possible.
 

General Posters
7:00 PM-9:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, August 20, 2007 BCEC -- Exhibit Hall - B2, Sci-Mix

Division of Analytical Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007