CARB 90 |
| Sialic acids normally appear at the terminal positions of glycoproteins and glycolipids where they are alpha(2,3)- or (2,6)- linked to galactosides or alpha (2,6)- linked to 2-acetamido-galactosyl residues. The appreciation of the biological importance and therapeutic potential of sialic acid and its derivatives has been limited by certain weaknesses in the methods for chemical sialylation. In order to cover these gaps, novel sialylation methods, structural modifications, and enzymatic approaches emerged at the turn of the century. Herein we describe the recent developments in sialylation reactions using thioimidoyl and thiophenyl sialosyl donors bearing different C-5 functionalities, and their application in various reaction conditions for the stereoselective synthesis of alpha sialosides. |
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General Posters
6:00 PM-8:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster
Sci-Mix
Division of Carbohydrate Chemistry |