Supramolecular nanominietics: Replication of viruses, micelles, and other soft, self-assembled nanoscale objects

POLY 69

Benjamin Maynor, ben.maynor@liquidia.com1, Isaac LaRue, ilarue@email.unc.edu2, Jason P. Rolland, jason.rolland@liquidia.com1, Ashish A. Pandya3, Zhaokang Hu2, Sergei S. Sheiko, sergei@email.unc.edu2, and Joseph DeSimone, desimone@unc.edu2. (1) Liquidia Technologies, P.O. Box 110085, Research Triangle Park, NC 27709, (2) Department of Chemistry, University of North Carolina, CB#3290 Venable Hall, Chapel Hill, NC 27599-3290, (3) Department of Chemistry, University of North Carolina at Chapel Hill, B-5 Venable Hall, Chapel Hill, NC 27599
Naturally-occurring supramolecular objects, such as micelles and viruses, exhibit sophisticated morphological shapes or surface motifs that conventional synthetic and fabrication techniques cannot replicate. However, self-assembly of these structures requires highly specific molecular interactions and benign environmental conditions to ensure the formation of fragile objects. Here, we report a nanofabrication technology that allows the creation of both natural and synthetic self-assembled objects with nanometer-scale fidelity. Adenoviruses and block-copolymer micelles have been molded using ultralow surface energy and low viscosity fluoropolymers to capture these shapes in a permanent, nonstick mold. Such molds can in turn be employed to replicate the self-assembled shapes from a wide range of materials. In sharp contrast to the simple geometric structures typically produced by molding technologies using man-made microfabricated master templates, this process permits high-definition replication of a wide variety of self-assembled and weakly adhering nano-objects, which may have applications in sensing, materials science, and medicine..