Annexin-A5 binding block copolymer nanoparticles

POLY 87

Vanessa Schmidt, schmidt@enscpb.fr1, Cristiano Giacomelli, giacomelli@enscpb.fr1, François Lecolley, lecolley@enscpb.fr1, Joséphine Lai-Kee-Him2, Alain R. Brisson2, and Redouane Borsali, borsali@enscpb.fr3. (1) Laboratoire de Chimie des Polymeres Organiques (LCPO), ENSCPB-Universite Bordeaux 1, 16 Av. Pey Berland, Pessac Cedex, 33607, France, (2) Université Bordeaux 1, Laboratoire d’Imagerie Moléculaire et NanoBioTechnologie - IECB, 2 Rue Robert Escarpit, Pessac Cedex, 33607, France, (3) Laboratoire de Chimie des Polymeres Organiques, LCPO-CNRS-ENSCPB, University of Bordeaux, 16 Avenue Pey-Berland, Pessac, 33607, France
The formation of protein-decorated nano-sized polymeric particles is described. Annexin-A5 protein binding to micellar aggregates having poly((1-ethoxycarbonyl)vinylphosphonic diacid) (PECVPD) and poly(n-butyl acrylate) (PBuA) as corona- and core-forming segments, respectively, was evidenced by Static and Dynamic Light Scattering (SDLS), cryo-Transmission Electron Microscopy (cryo-TEM) and Quartz Crystal Microbalance with Dissipation monitoring (QCM-D) experiments. These new objects find potential applications, as for example in micelle-mediated target drug delivery and controlled fabrication of biochips.
 

General Papers: Polymers in Nanotechnology
1:00 PM-5:00 PM, Sunday, August 19, 2007 Westin Boston Waterfront -- Douglas, Oral

Division of Polymer Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007