MEDI 71 |
| Proteases are important in many physiological processes but may also have an adverse effect in propagating diseases like cancer, osteoporosis, and arthritis. The latter characteristic of proteases surfaces the role of protease inhibitors. Current research efforts are centered on the synthesis and elaboration of 2-amino-4-carboxy cyclobutanone 1, a novel amino acid, which may be elaborated in both the P and P' directions, and toward the synthesis and functionalization of 2-amino-4,4-difluorocyclobutanone 2, which is structurally related to trifluoromethyl ketones that have been successfully employed as serine and cysteine protease inhibitors.
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Poster Session
7:00 PM-9:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Medicinal Chemistry |
