AGRO 37 |
| In this study, four monoterpenoids (pulegone, thymol, α-terpineol, and linalool) were using to investigate their effects on [3H]-TBOB (t-butylbicycloorthobenzoate) binding to adult mouse GABA (γ-aminobutyric acid) receptors. Those four types of monoterpenoids have different patterns on modulating the binding of [3H]-TBOB to GABA receptor. Pulegone inhibited the binding of [3H]-TBOB with IC50 = 30mM. The other 3 monoterpenoids potentiated the [3H]-TBOB binding to the GABA receptor with the maximum potentiation of 143% (thymol), 127% (α-terpineol), and 156% (linalool). The data suggested that pulegone binds to GABA receptor as the same binding site as [3H]-TBOB, and pulegone may affect GABA receptor as a non-competitive antagonist. The increasing of [3H]-TBOB binding indicated the interaction of GABA receptor and the other three monoterpenoids, but the binding sites of them are different from the [3H]-TBOB. |
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Agrochemical Education Awards For Graduate Student Travel
8:00 AM-11:00 AM, Monday, August 20, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Agrochemicals |