Synthesis, characterizations, and fluorescence and cytotoxicity studies of rhenium(I) tosylato complexes

INOR 169

Saroj K. Pramanik, sarojpramanik@yahoo.ca1, Dwayne A. Hill, hilllab@yahoo.com1, Gregory K. Haynes, ghaynes@morgan.edu2, Maurice O Iwunze, miwunze@morgan.edu2, George E. Greco, ggreco@goucher.edu3, Douglas M. Ho, ho@princeton.edu4, Jeanette A. Krause, jeanette.krause@uc.edu5, and Santosh K. Mandal, smandal@morgan.edu2. (1) Department of Biology, Morgan State University, 1700 E. Cold Spring Lane, Baltimore, MD 21251, (2) Department of Chemistry, Morgan State University, 1700 E. Cold Spring Lane, Baltimore, MD 21251, (3) Department of Chemistry, Goucher College, 1021 Dulaney Valley Road, Baltimore, MD 21204, (4) Department of Chemistry, Princeton University, Princeton, NJ 08544-1009, (5) Chemistry, University of Cincinnati, Cincinnati, OH 45221
Rhenium(I) tricarbonyl (a-diimine) complexes of the type, fac-(CO)3(a-diimine)ReX are of importance because they exhibit luminescence in the solid-state and in fluid solutions. During the course of our research on the reactions of Re2(CO)10 with various a-diimines in alcohols, we observed that the tosylato complexes, fac-(CO)3(a-diimine)ReOTs can be obtained in high yields from one-pot reactions of Re2(CO)10 with diimines in alcohols in the presence of carbon dioxide and subsequent treatments of the above products with p-toluene sulfonic acid (HOTs). The tosylato complexes were characterized spectroscopically and in some cases through X-ray crystal structure determinations. As expected, the tosylato complexes exhibit fluorescence in the solid-state and in fluid solutions. Surprisingly, the tosylato complexes are cytotoxic against numerous cancer cell lines.
 

Applications of Organometallic Chemistry
7:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Inorganic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007