Toward transcriptional therapy with programmable DNA binding oligomers

BIOL 150

Peter B. Dervan, dervan@caltech.edu, Department of Chemistry, California Institute of Technology, Mail Code 164-30, Pasadena, CA 91125
Many diseases, such as cancer, are related to aberrant gene expression. Regulating transcription by chemical methods could be important in human medicine. Synthetic molecules, programmed to read the DNA double helix by a set of simple chemical principles, achieve affinities and specificities comparable to DNA-binding proteins. Current research efforts are focused on the regulation of endogenous genes in cell culture and the design of artificial transcription factors.
 

Eli Lilly Award Symposium
9:00 AM-11:40 AM, Wednesday, August 22, 2007 BCEC -- 109A, Oral

Division of Biological Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007