INOR 150 |
| Dirhodium(II,II) carboxylate compounds covalently bind to duplex DNA. Control of DNA-binding kinetics and intra/inter-strand DNA adduct profile is dependent upon the number and nature of the bidentate carboxylate ligands. We have further characterized the nature of these covalent Rh-DNA adducts by reaction of double-stranded salmon testes DNA with a series of dirhodium (II,II) compounds followed by digestion with DNaseI, P1nuclease, and alkaline phosphatase enzymes. Nature of DNA adducts formed by these dirhodium compounds will be discussed as characterized by rhodium AAS, HPLC and mass spectrometry. |
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Bioinorganic Chemistry: DNA and RNA
1:30 PM-5:30 PM, Sunday, August 19, 2007 BCEC -- 211, Oral
Division of Inorganic Chemistry |