COLL 251 |
| A major challenge in the field of biomaterials is the prevention of nonspecific protein adsorption on surfaces. With an understanding of the nonfouling mechanism, new groups of nonfouling materials have been developed and demonstrated in our lab. Fundamentally, nonfouling materials are a group of materials with highly hydrated layers and optimized nanometer structures. This mechanism has been developed through well controlled model systems of PEG and mixed charged SAMs at the nanometer scale. Extensive methods, such as molecular simulation, atomic force microscope (AFM), electron spectroscopy for chemical analysis (ESCA), attenuated total reflection fourier transform infrared (ATR-FTIR) and surface plasmon resonance (SPR), were used to reveal the secret of the nonfouling mechanism. Based on this understanding, we demonstrate that highly hydrated poly(sulfobetaine methacrylate) and poly(carboxybetain methacrylate) are excellent nonfouling materials. They not only can prevent protein adsorption in whole plasma, but also can prevent both Gram-positive and Gram-negative bacteria adsorption. Furthermore, a new group of materials were developed through the mixed charge concept, which makes zwitterionic materials more practical for various applications. |
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Fundamental Research in Colloid and Surface Chemistry
6:00 PM-8:00 PM, Monday, August 20, 2007 BCEC -- East Registration, Poster
Division of Colloid & Surface Chemistry |