ANYL 205 |
| Chiral analyses for a special branch of analytical chemistry. While there are a number of very general approaches to non-chiral HPLC, chiral HPLC relies on a large number of stationary phases, each with a narrower range of (often unpredictable) chiral selectivity. A new chiral material has been developed with a novel mechanism for chiral selectivity, believed to be more like a chiral exclusion than a chiral analyte-chiral ligand interaction. This mechanism allows chiral selectivity to be decoupled from other chromatographic properties of the stationary phase. A number of non-chiral surface chemical treatments have been performed on this material to determine whether a chiral stationary phase can be developed with good selectivity across a broad range of molecules and good normal phase chromatographic characteristics. Several chemistries will be compared and chromatographic data presented for ionizable pharmaceutical molecules. |
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General Posters
7:00 PM-9:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Sci-Mix
Division of Analytical Chemistry |