POLY 133 |
| Varying compositions of Poly(methyl methacrylate-b-butylacrylate-b-methyl methacrylate) P(MMA-BA-MMA) and poly(styrene-b-butyl acrylate-b-styrene) P(S-BA-S) copolymers have been evaluated as drug delivery coatings for coronary stent applications. The coated stents were evaluated for coating integrity and paclitaxel (PTx) release. All copolymers exhibited thermoplastic elastomeric properties that resulted in excellent stent coating performance with robust properties when loaded with PTx. Differential scanning calorimetry (DSC) confirmed the presence of two separate Tgs, typical of a phase separated block copolymer. Evaluation of these copolymers blended with PTx indicated that PTx is miscible with PMMA, partially miscible with PBA, and completely immiscible with PS. The PTx release profile may be governed by miscibility of PTx with the block copolymer segments, in addition to the hydrophilicity and the polarity of the polymers. Thus, control of drug release was achieved through modification of the copolymer segments and composition. |
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General Papers: Functional Materials
6:00 PM-8:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Polymer Chemistry |