Application of "click " chemistry to CdSe quantum dots

CHED 255

Kristopher A. Tantillo, tantillo@mit.edu, Rebecca C. Somers, rsomers@mit.edu, Preston T. Snee, Moungi G. Bawendi, mgb@mit.edu, and Daniel G. Nocera, nocera@mit.edu. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Ave Rm. 2-209, Cambridge, MA 02139
Click chemistry is popular in coupling chemistry because of its simplicity and biocompatibility. The application of click chemistry to CdSe quantum dots, however, has been limited because copper ions, which catalyze the cycloaddition, lower the quantum yield of the dots. In light of this, other strategies for click chemistry, such as the use of a strained cyclooctyne ring or thermal activation, were pursued. Fluorescent dyes were coupled via click chemistry to quantum dots without quenching the CdSe luminescence, and the photophysics and energy transfer of these systems were examined. This methodology offers a general strategy to prepare useful bioconjugated quantum dots.
 

Undergraduate Research Poster Session
2:30 PM-4:30 PM, Monday, August 20, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Chemical Education

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007