CHED 275 |
| In our Merck Scholars and student coop programs, undergraduates in the chemistry department have the opportunity to undertake significant research projects. As part of our program to develop targeting agents for nanoparticle based drug delivery systems using a module assembly approach, we selected the 6,7-dialkoxy-4-anilinoquinazolines as the scaffold for one of the targeting modules. This class of compounds possesses potent activity against growth factor receptor tyrosine kinases, thereby serving as a targeting mechanism. Structure activity relationships indicate that significant substituent tolerance is present at the 3-position of the aniline group as well as at the 6- and 7-alkoxy positions. In this presentation, we will describe the synthesis of new alkynylated derivatives of the 4-anilinoquinazolines and their coupling to a variety of azide-containing reagents. |
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Undergraduate Research Poster Session
2:30 PM-4:30 PM, Monday, August 20, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Chemical Education |