Controlling self-assembly reactivity in DNA- and protein-nanoparticle systems

INOR 268

Mathew M. Maye, mmaye@bnl.gov1, Dmytro Nykypanchuk1, Paul Freimuth2, Daniel van der Lelie1, and Oleg Gang1. (1) Center for Functional Nanomaterials, Brookhaven National Laboratory, Bldg 463, Upton, NY 11973, (2) Biology Department, Brookhaven National Laboratory, Upton, NY 11973
The use of bio-inspired approaches for nanoparticle self-assembly takes advantage of the natural tunability and addressability of encoded biomolecular interactions between particles. We have recently been utilizing the tunable structural properties of DNA and Proteins for nanoparticle assembly. In DNA systems, by controlling the type, number, and the rigidity of the nanoparticles DNA-capping, we are able to fine-tune assembly kinetics, relative aggregate size and morphology. In Protein systems, we have utilized the novel three-fold symmetry of the knob domains of Adenovirus serotype 2 for particle assembly and functionalization. A series of genetically expressed knob mutants were developed, and assembly reactivity was shown to be dependent upon the position and type of mutation at the knob protein interface. The observed control over assembly morphology and interparticle spatial properties in these systems may aid in the design and construction of increasingly complex systems with desirable biomedical, optical and electronic applications.
 

Nanoscience: Applications
7:00 PM-10:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, August 20, 2007 BCEC -- Exhibit Hall - B2, Sci-Mix

Division of Inorganic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007