Toward sequential growth factor delivery from scaffold surfaces

POLY 536

Mara L Macdonald, maralee@mit.edu1, Nicole Brenner2, Girma Endale3, Natalia Rodriguez4, Robert Langer, rlanger@mit.edu5, and Paula T. Hammond, Hammond@mit.edu5. (1) Harvard-MIT Division of Health Sciences and Technology, 77 Massachusetts Avenue, E25-519, Cambridge, MA 02139, (2) Yale University, (3) Roxbury Community College, (4) Chemical Engineering, Massachusetts Institute of Technology, (5) Department of Chemical Engineering and Harvard-MIT Division of Health Sciences and Technology, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Room E25-342, Cambridge, MA 02139
An interest in improving cell/surface interactions for the purpose of enhancing integration of implanted medical devices (such as hip implants or stents), as well as improving drug delivery from regenerative medicine scaffolds has driven our interest in the possibility of sequential release of growth factors from surfaces. By using an aqueous layer-by-layer incorporation strategy, we are able to preserve fragile drug function, have nanometer scale control over incorporation, and finely tune the level of growth factors available in each degradable layer. Herein is described a system that has the potential to sequentially deliver sufficient quantities of active growth factors (basic fibroblast growth factor and bone morphogenetic protein 2) to enhance proliferation and differentiation of osteoblast progenitor cells towards bone formation.
 

Scaffolds and Matrices for Tissue Engineering and Regenerative Medicine Applications
8:30 AM-11:40 AM, Wednesday, August 22, 2007 Westin Boston Waterfront -- Grand Ballroom B, Oral

Division of Polymer Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007