Using surface chemistry approach to control stem cells' differentiation

BIOL 105

Wei Luo, wluo@email.unc.edu1, Eugene WL. Chan, ewlchan@email.unc.edu1, and Muhammad N. Yousaf, mnyousaf@email.unc.edu2. (1) Department of Chemistry, University of North Carolina-Chapel Hill, Venable B-5/Kenan 807A, Chapel Hill, NC 27599, (2) Department of Chemistry, University of North Carolina - Chapel Hill, CB #3290, Chapel Hill, NC 27599
While stem cells can be used as a promising source of cell transplantation therapies, control of differentiation is still challenging and little is known about the crucial factors that influence stem cell differentiation. Although it was recognized that stem cells can be controlled by particular microenvironments, the identification and manipulation of stem cells and their surroundings are very difficult. In our work, we developed a novel technology to make a biocompatible model substrate, on which multiplex surface arrays can be achieved. Based on this model substrate, parallel study and high-throughput screening of various cell-material interactions can be accomplished. By manipulating and characterizing the surface environments, we can reach a new level of regulating stem cells differentiation.
 

Frontiers in Chemical Biology
5:00 PM-7:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Biological Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007