POLY 4 |
| Ammonium polyionenes are polymers that contain quaternary nitrogen atoms in the macromolecular backbone of the repeating unit. Polyionenes have many potential uses in biomedical applications, including antimicrobial applications or DNA delivery. The charge density, hydrophobicity, and molecular weight dictate whether a polyionene is suitable for DNA delivery or antimicrobial applications. A series of 12,12-ammonium polyionenes were successfully synthesized with various molar ratios of di-tertiary amine to dihalide. The mechanical properties were evaluated using dynamic mechanical analysis and tensile testing. The cell viability and gene transfection abilities of the ionene polymers will be described. Polymer conjugation to peptides has emerged as an important topic in polymer science. Poly(ethylene glycol) – glutathione materials were synthesized with the potential to deliver glutathione, an endogenous antioxidant, to specific cell receptors. GSH-PEG-GSH nanoparticles were characterized via dynamic light scattering and transmission electron microscopy. |
|
Synthetic and Biological Macromolecules for Emerging Nanotechnologies
8:30 AM-12:00 PM, Sunday, August 19, 2007 Westin Boston Waterfront -- Grand Ballroom A, Oral
Division of Polymer Chemistry |