Natural product discovery

BIOL 142

Jon Clardy, jon_clardy@hms.harvard.edu, Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, 240 Longwood Avenue, Boston, MA 02115
The discovery of a new biologically active natural product in a phenotypic screen leads to the search for its target. This talk will stress tactics for such discovery using examples from antimalarial drug discovery, behavioral studies of the model organism Caenorhabditis elegans, signaling agents produced by interacting bacteria from frequently encountered soil genera, and microorganisms associated with the Southern Pine Beetle (Dendroctonus frontalis).