BIOL 148 |
| The talk will attempt to demonstrate by example that there have been major advances in the methodology of chemical synthesis. The remarkable discoveries in the field of synthetic methodology, in particular, through the use of organometallic catalysis, have enabled chemical synthesis to attack much more ambitious agenda problems than was hitherto possible. In our judgment, it is primarily advances in chemical methodology, which have enabled new insights at the strategic level. The lecture will show by illustration that these advances can serve to enhance the possibilities of utilizing small molecule natural products and not-so-small biologically active substances, as entry points for medicinal discovery. The tendency to down-grade the utility of natural product leads in pharma discovery arose from concerns primarily about issues of compound availability. The revolution in the power and reach of synthesis described above has altered the paradigm. |
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Eli Lilly Award Symposium
9:00 AM-11:40 AM, Wednesday, August 22, 2007 BCEC -- 109A, Oral
Division of Biological Chemistry |