MEDI 270 |
| Littorachalcone, a biologically active polyphenol, was found to be useful in the treatment of various neurological disorders including Parkinson's and Alzheimer's disease. A direct and convergent synthesis of littorachalcone will be presented. A bis-aldol reaction was used as a key step involving 2,4-dimethoxyacetophenone and suitably functionalized 4,4'-oxybisbenzaldehyde. Reduction of resulting bis-enone by NiCl2-NaBH4 followed by removal of protecting groups furnished the target molecule in an efficient manner. |
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Poster Session
7:00 PM-9:00 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Medicinal Chemistry |