CINF 3 |
| Over the past decade, and despite major advances in new technologies, the pharmaceutical sector has witnessed how the number of new drugs introduced in the market every year has stayed level or decreased while the cost of drug discovery and development has significantly increased. The safety of drugs used in clinical practice is under constant scrutiny and the withdrawal of several compounds in recent years confirms the serious productivity challenges faced by modern biomedical research. BioEpisteme, a knowledge-based project, was initiated to overcome these productivity bottlenecks and to contribute to the faster discovery of new and safer drugs, as well as the finding of new uses for known molecules. In-house developed datamining algorithms have led to a model that characterizes more than 400 different molecular mechanisms of action simultaneously. The development of the project and its application in explaining new therapeutic applications for angiotensin AT1 antagonists will be presented. |
|
Drug Reprofiling
8:25 AM-12:10 PM, Sunday, August 19, 2007 BCEC -- 252 A, Oral
Division of Chemical Information |