ANYL 343 |
| Early and relevant assessment of small molecule DMPK properties plays a pivotal role in the drug discovery process at Merck Research Laboratories Boston. Our group has adopted a generalist support approach, wherein each staff member performs a full breadth of DMPK activities. Therefore, we faced the challenge of developing versatile, generic, scalable, and cost-effective lab processes amenable to a diverse workload. This proposed operational framework favors broad implementation of automated processes, both for liquid handling and LC-MS driven data analysis. Herein, we discuss the realization of this integrated support philosophy at MRL Boston. One multifunctional liquid handling system is currently employed for fully automated work-up of all in vivo samples, as well as for execution of all key in vitro DM assays. For quantitative analysis, all generated samples funnel into multi-channel LC-MS systems enabled for automated compound tuning, data acquisition, and analysis. This liquid handling/LC-MS instrument nucleus has been successfully deployed for rapid and flexible compound evaluation against the major in vivo and in vitro decision-driving discovery DMPK parameters. |
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Analytical Technology for Drug Discovery
8:30 AM-11:50 AM, Tuesday, August 21, 2007 BCEC -- 105, Oral
Division of Analytical Chemistry |