TOXI 12 |
| Many nitrosamines are powerful carcinogens. Their biological activity is due to the formation of á-hydroxynitrosamines through metabolic activation. The á-hydroxynitrosamines decompose to form diazonium ions which can alkylate DNA. Compared to other classical alkylating agents, simple diazonium ions alkylate DNA with enhanced selectivity toward the oxygen atoms of nucleobases. The resulting oxygen adducts have been shown to give rise to mutations with high frequency. Therefore, it is of great importance to understand the factors that account for the preference of diazonium ions for oxygen atoms of nucleobases. This work was carried out to examine a recently-devised model concerning the factors that dictate atom site selectivity in the alkylation of DNA by 1-propanediazonium ion1. Reference: 1. Lu, X.; Heilman, J. M.; Blans, P.; and Fishbein, J. C. The structure of DNA dictates purine atom site selectivity in alkylation by primary diazonium ions. Chem. Res. Toxicol. 2005, 18, 1462 |
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Young Investigator Session
8:15 AM-12:00 PM, Monday, August 20, 2007 BCEC -- 258C, Oral
Division of Chemical Toxicology |