INOR 99 |
| Numerous enzymes take advantage of the cooperative action of two proximate metal ions within their active site, in particular for multielectron redox transformations (e.g., for the activation of O2 at dicopper sites and subsequent oxygenation and oxidation chemistry). These natural systems represent a guiding line for novel bioinspired catalysts. We have prepared a series of highly preorganized bimetallic complexes based on compartmental pyrazolate ligands, in which molecular parameters such as the metal-metal separation can be tuned by appropriate modifications of the ligand scaffold. These systems allow to study structure/activity correlations in two-center reactivity. Selected examples of copper-mediated oxidation reactions as well as insight into structural and electronic details of O2-activation at the multicopper sites will be presented. Acknowledgement: This work is supported by the DFG (International Research Training Group GRK 1422). |
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Inorganic Modeling of Biological Systems
1:30 PM-5:10 PM, Sunday, August 19, 2007 BCEC -- 208, Oral
Division of Inorganic Chemistry |