Challenging course on medicinal chemistry for non-science majors

CHED 403

Martín G. Zysmilich, mgz@gwu.edu, Department of Chemistry, The George Washington University, 725 21st Street NW, Washington, DC 20052
When trying to develop courses for non-science majors a dilemma usually arises: should one first choose a textbook and build the course around it? Or decide what one would like to teach and then hope one could find the perfect textbook for the course? I have found myself in both situations. For one course that focuses on environmental chemistry, the first scenario applied. For the other course, medicinal chemistry for non-science majors, I have not yet found an appropriate textbook. I have chosen to teach this course in a more challenging fashion, by describing the actual mechanisms of drug action and not, as most available textbooks present the subject, by listing the different available drugs for each problem and showing their chemical structures. In this presentation I will describe the syllabus of the course, and how the conceptual base of the students is built up to understand simple drug action mechanisms, such as antihistamines, to more complex processes, namely HIV infection, antiviral, and anticancer drugs.