COMP 353 |
| Protein structure determination is crucial in the elucidation of protein function. Present experimental methods, however, are costly and time-consuming. But how much experimental data is really needed to predict a protein's structure? We will present a fast and inexpensive structure prediction method that seeks to answer this question. Our method involves three steps: (1) building a decoy set, (2) using a small number of experimental inter-residue distances, and (3) comparing the measured distances with those calculated for each decoy. We postulate that structures with several similar distances will also have similar three-dimensional structure. Using two different types of decoy sets, general and specific, we make structure predictions for several CASP7 target proteins. We will also compare our method to others. |
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Chemical Computing Group Excellence Award
6:00 PM-8:00 PM, Tuesday, August 21, 2007 BCEC -- Ballroom Foyer, Poster
Division of Computers in Chemistry |