ANYL 208 |
| One of the key requirements for regenerative medicine is the design of biologically compatible scaffolds that can be readily adopted by the body system without harm. Designs of synthetic polymeric biomaterials for tissue regeneration have been focused on mimicking natural extra cellular environment since the nano-structure of the subcellular basement membrane/scaffold is an important determinant of how cells assemble ex vivo into functional tissues. Electrospun nanofibers have gained much attention in recent years since they mimic the natural extracellular matrix. The present study involves the design of peptide amphiphiles and their incorporation onto polymer nanofibers to develop biocompatible scaffolds. Amphiphilic peptide sequences were designed and modified with different cell adhesion motifs to improve their efficiency. Our results showed that cell adhesion properties of the PVA nanofibers enhanced successfully via the incorporation of peptides with cell adhesion motifs. Cell proliferation studies showed that more than 60% of cells were proliferating on the scaffolds. The modified nanofiber scaffold, serves as an artificial niche which mimics the natural extracellular matrix, making it promising for tissue engineering applications. |
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General Posters
7:00 PM-9:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Sci-Mix
Division of Analytical Chemistry |