TOXI 99 |
| The evolving field of nanotechnology raises concern regarding their environmental and health impacts. Future applications of nanoparticles could be challenged by the lack of specific safety information. We have taken up the challenge to fill those knowledge gaps, through toxicology studies of silver nanoparticle, which is a promising antimicrobial drug. This report highlights the results from our latest work on the impact of silver nanoparticles on both, in vivo (Zebrafish embryos) and in vitro systems (cell lines). Toxicity was assessed through viability, morphological changes, genotoxicity and biodistribution. Surprisingly, silver nanoparticles were found to exhibit the potential to cause genotoxicity in the form of chromosomal aberrations and DNA damage. Moreover, they induced proliferation arrest in cell lines and growth retardation in embryos. Electron microscopic images further confirmed the nuclear affinity of the particles. Conclusively, silver nanoparticles were found to be cytotoxic and their uncontrolled application could pose a serious threat to the environment and health. |
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Poster Session and Awards
6:00 PM-10:00 PM, Tuesday, August 21, 2007 BCEC -- 204 A/B, Poster
Division of Chemical Toxicology |