Analogs of orotidine monophosphate (OMP): Their effect on the activity of OMP decarboxylase

MEDI 66

Srinath Thirumalairajan, sri@dal.ca and Stephen L. Bearne, sbearne@dal.ca. Department of Biochemistry and Molecular Biology, Dalhousie University, 5850 College Street, Sir Charles Tupper Medical Building, Halifax, NS B3H 1X5, Canada
Orotidine monophosphate decarboxylase (ODCase) catalyzes the decarboxylation of OMP to yield UMP in the pathway for the de novo biosynthesis of pyrimidines. The enzyme effects catalysis with a very high catalytic proficiency and without the aid of any cofactors or metal ions. Structural and electronic analogues of OMP that are modified at the 6-position of the pyrimidine base have been designed and synthesized. The effects of these analogues on the activity of ODCase will be presented.
 

Poster Session
7:00 PM-9:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, August 20, 2007 BCEC -- Exhibit Hall - B2, Sci-Mix

Division of Medicinal Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007