Microfluidic devices for bioanalytical analysis

ANYL 334

Christopher T. Culbertson, culbert@ksu.edu, Scott A. Klasner, and Alexander K. Price, pricea2@slu.edu. Department of Chemistry, Kansas State University, Manhattan, KS 66506
Microfluidic devices have a variety of advantages that make them particularly well suited to the analysis of single cells and small volume biological samples. These advantages include 1) the ability to integrate multiple chemical processing operations onto a single substrate, 2) channels of dimensions similar to the size of individual cells, 3) low volumetric flow rates, 4) substrate materials which are biologically compatible, and 5) the ability to perform high efficiency separations at speeds much faster than can be performed using conventional capillary electrophoresis. The application of these devices for the analysis of single cells and limited volume biological samples will be presented and discussed.