Mechanism of the fluorinase from Streptomyces cattleya

FLUO 20

David O'Hagan, do1@st-andrews.ac.uk, School of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST, United Kingdom, James H Naismith, naismith@st-andrews.ac.uk, Centre for Biomolecular Science, University of St. Andrews, North Haugh, St. Andrews, Scotland, KY16 9ST, United Kingdom, and Xiaofeng Zhu, xz10@st-andrews.ac.uk, Department of Chemistry, University of St Andrews, North Haugh, St Andrews, KY16 9ST.
The fluorinase enzyme, isolated from Streptomyces cattleya, is unusual in that it catalyses C-F bond formation from fluoride ion. The mechanism of this enzyme has been explored in detail using crystallography, site directed mutagenesis, kinetic and calorimetry studies. Our recent results will be reported which gain a deeper understanding of how this unusual enzyme works.
 

Nanostructured Fluorocarbons: Smart Tectons for Self-Assembly
2:00 PM-4:25 PM, Monday, August 20, 2007 BCEC -- 252B, Oral

Division of Fluorine Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007