Platinum–DNA interactions: Structures and consequences

CARB 31

Stephen J. Lippard, Department of Chemistry, Massachusetts Institute of Technology, Cambridge, MA 02139
Platinum anticancer drugs target DNA. We shall present the latest work from our laboratory characterizing the interactions of platinum anticancer drugs and/or new drug candidates with DNA and nucleosomes. Both structural and mechanistic studies will be described. This work has been supported by the National Cancer Institute.