Construction of functionalized catalysts using monoclonal antibodies with nonchiral rhodium complexes

POLY 430

Hiroyasu Yamaguchi, hiroyasu@chem.sci.osaka-u.ac.jp, Tohko Hirano, Hideaki Kiminami, and Akira Harada. Department of Macromolecular Science, Graduate School of Science, Osaka University, 1-1 Machikaneyama, Toyonaka, Osaka, 560-0043, Japan
We have succeeded in incorporating a transition metal complex, non-chiral Rh complex, into the binding sites of monoclonal antibodies. One of the antibody-Rh complexes catalyzed the hydrogenation of amino acid precursors to give L-amino acid ((S)-enantiomer) in high (>98%) enantiomeric excess with a substrate specificity (Figure 1). This work represents the first example of asymmetric hydrogenation of an amino acid precursor catalyzed by the complex of a transition metal with immunoglobulin. The antibody-Rh complex was found to be a precise stereoselective catalyst through second-sphere coordination.

 

Metal-Containing and Metallo-Supramolecular Polymers and Materials
6:00 PM-8:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Polymer Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007