POLY 540 |
| Sol-gel transition systems of biodegradable polymers aq. solution in response to a change in temperature has been widely investigated, because such system has a possibility for an injectable drug delivery system for sustained drug release and in situ cell delivery with scaffold for tissue regeneration. In this study, to obtain temperature-responsive gelling polymer exhibiting high mechanical strength in gel state, the conjugate of star-shaped 8-arms PEG-b-PLLA with cholesterol moiety was synthesized. The obtained conjugate showed sol-gel transition at 36°C and the mechanical strength of the hydrogel formed was higher than the previously reported biodegradable temperature-responsive gelling polymers. The possibility of the conjugate as a novel injectable scaffold for tissue regeneration was investigated through the temperature-responsive behavior of the conjugate, mechanical and degradation properties of the hydorgel, and cell proliferation inside of the hydrogel. The good cell proliferation inside of the hydrogel was observed. |
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Scaffolds and Matrices for Tissue Engineering and Regenerative Medicine Applications
8:30 AM-11:40 AM, Wednesday, August 22, 2007 Westin Boston Waterfront -- Grand Ballroom B, Oral
Division of Polymer Chemistry |