POLY 48 |
| The use of protein-polysaccharide interactions in the production of biomaterials may mimic certain features of the biological environment and be responsive to appropriate biological cues. We have employed interactions between the glycosaminoglycan heparin and heparin-binding proteins in the noncovalent assembly of heparin-functionalized poly(ethylene glycol) polymers. The production of multiple types of polymeric matrices functionalized with these macromolecules has also been demonstrated. Immunochemical assays suggest that, with appropriate modification of the hydrogels and fibers, growth factors can be easily immobilized in the matrices and delivered in a stimuli-responsive manner and/or with temporal control. The proteins are released from the hydrogels over timescales relevant for neovascularization and wound healing and retain their biological activity as assessed via cellular assays. The combination of these results suggests the potential application of these types of materials in targeted delivery and soft tissue engineering. |
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Synthetic and Biological Macromolecules for Emerging Nanotechnologies
1:30 PM-5:30 PM, Sunday, August 19, 2007 Westin Boston Waterfront -- Grand Ballroom A, Oral
Division of Polymer Chemistry |