Synthesis of chlorambucil analogs

CHED 334

Asma Khetani, khetaniasma@yahoo.com1, Gopal Subramaniam, gopal.subramaniam@qc.cuny.edu2, Wilma Saffran2, and Sasan Karimi1. (1) Department of Chemistry, Queensborough Community College-CUNY, 222-05 56th Ave., Bayside, NY 11364, (2) Department of Chemistry and Biochemistry, Queens College-CUNY, 65-30 Kissena Boulevard, Flushing, NY 11367
Chlorambucil is a chemotherapy drug that has been used in the treatment of leukemia, ovarian and breast cancer, and various autoimmune diseases. Chlorambucil is an alkylating agent that binds to DNA and RNA preventing the replication of the cell. This drug is also known to be a carcinogen and teratogen. It is the objective of this investigation to synthesize analogs of chlorambucil while decreasing its toxicity. We have synthesized several new analogs of chlorambucil amides; namely, the cyclohexyl and diethyl derivatives from the chlorambucil acyl chloride. The activity of these compounds will be tested with DNA.
 

Undergraduate Research Poster Session
2:30 PM-4:30 PM, Monday, August 20, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Chemical Education

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007