Surface-engineered quantum dot nanoparticles for cellular imaging and delivery of therapeutic agents

ANYL 309

Shuming Nie, snie@emory.edu1, Hongwei Duan, hduan@emory.edu2, and Min Kuang, mkuang@emory.edu2. (1) Departments of Biomedical Engineering, Chemistry, Materials Science and Engineering, Hematology and Oncology, Emory University and Georgia Institute of Technology, 101 Woodruff Circle, Suite 2001, Atlanta, GA 30322, (2) Departments of Biomedical Engineering and Chemistry, Emory University and Georgia Institute of Technology, 101 Woodruff Circle Suite 2001, Atlanta, GA 30322
The development of sensitive detection probes, which enable rapid and selective determination of the temporal and spatial distribution of specific biomolecules, has been one of the central goals of biomedical research. Recently, probes based on semiconductor quantum dots (QDs) started playing significant roles in cellular or in vivo fluorescent imaging. Rational designs of QD surface chemistry are essential for controlling the hydrodynamic sizes, non-specific binding and bioconjugation chemistry, which are all key issues for the application of QDs as bioimaging labels. This talk will review some of the surface coating methods developed in our group for specific bioimaging application. Especially, we will discuss the recent advances of using QDs coated with amphiphilic copolymers and polyethylenimine derivatives for living cell imaging and for tracking the delivery of therapeutic agents, such as anticancer drugs.
 

Nano-Biochemistry and Technology
1:30 PM-5:00 PM, Monday, August 20, 2007 BCEC -- 104B, Oral

Division of Analytical Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007