INOR 81 |
| Nitric oxide mediates a variety of biological processes. To understand the roles of NO in biological contexts, sensing of NO in a manner that maps its spatial and temporal distribution is desirable. The absence of tools to detect NO directly, rapidly, specifically, and selectively motivated us to develop metal-based fluorescent probes to visualize NO in vivo. We prepared and investigated Co(II), Cu(II), Fe(II), Rh(II), and Ru(II) complexes as turn-on fluorescent NO sensors. Our studies have demonstrated that complexes of transition-metal ions bound to ligands containing fluorophore appendages are appropriate and practical for the direct and specific detection of NO in biology. This work was supported by the National Science Foundation. |
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Young Investigator Symposium
1:30 PM-5:30 PM, Sunday, August 19, 2007 BCEC -- 206 A/B, Oral
Division of Inorganic Chemistry |