We report novel molecules based in the ‘TAME' (TAME = 1,1,1-tris(aminomethyl)ethane) framework with aminoisoquinoline groups which detect Zn(II) using coordination-enhanced fluorescence (CEF) and photoinduced electron transfer (PET).  The TAME scaffold is chosen for selective Zn(II) detection over Cd(II), because it provides rigid coordination of smaller di- or trivalent metal ions such as Zn(II) or Ga(III), vs. larger ones such as In(III).  Appending electron-releasing groups on the isoquinoline chromophore gives lower-energy emission.  The synthesis of 1 (TAMEisoquin) and 2 (6,7-DMTI, where 6,7-DMTI=6,7-dimethoxyTAMEisoquin) and structure of [Zn-1](ClO₄)₂ will be described.  Photophysical studies indicate modest luminescent effects in Zn(1)]²⁺, namely a 15-fold enhancement of fluorescence vs. unbound 1 and quantum yield Φ_Zn-1 = 0.77%.  Notably, the response of 1 to Zn(II) is selective in that none of the metal ions Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Cd(II), Na(I), K(I), Ca(II) and Ag(I) show greater than a ± 1-fold effect on the luminescence intensity of 1.  This finding is attributed to the match of donor properties and cavity size of 1 to Zn(II).  The 6,7-dimethoxyisoquinoline chromophore was synthesized from the appropriately substituted 3,4-dimethoxybenzaldehyde in six steps giving 6,7-dimethoxy-1-isoquinolinecarboxaldehyde in 11.5% overall yield, unoptimized.  The aldehyde was then appended to the TAME framework via a Ni(II) mediated template reaction followed by NaBH₄ reduction and liberation of 6,7-DMTI (2) in 26.7% yield.  Photophysical studies revealed that in the presence of Zn(II) 2 emits in the UV (λ_ex=326nm, λ_em=360nm) but possesses an enhanced quantum yield Φ_Zn-2 = 12.7% as compared to Zn-1.  Likewise, the response of 2 to Zn(II) is selective in that none of the metal ions Mn(II), Fe(II), Co(II), Ni(II), Cu(II), Cd(II), Na(I), K(I), Ca(II) and Ag(I) show greater than a ± 2-fold effect on the luminescence intensity of 2.