PHYS 358 |
| Sequence-specific probe for detecting target DNA is the cornerstone of the genomics revolution and molecular diagnostics. Polyamide containing N-methylpyrroles is a type of small molecule which can recognize DNA with high specificity in minor groove. Herein we report electrochemical studies on the interaction of NO2ImImPyDp with DNA modified on the glassy carbon electrode without any mediator. The results shown that polyamide is capable of recognition DNA with sequence-specific by electrochemically. Secondly, we discovered that the peak current of nitroso/hydroxylamine couple, which is the intermediate of one electron reduction of NO2ImImPyDp, is remarkably increase on the modified electrode compared with the bare GCE. So, the polyamide is very useful probe for the development of the DNA-sensor. Projects(20573008,20472009)supported by NSFC. |
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Physical Chemistry Poster Session
7:00 PM-9:00 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Physical Chemistry |