ANYL 76 |
| Gold nanoparticles have found increasing applications in drug delivery, medical diagnostics and biosensing. This presentation discusses recent findings of an investigation of gold nanoparticles for probing the reactivity of homocysteine. This bio-interfacial reactivity is interesting because a concentration of >15µM homocysteine in blood is considered to be an indication of cardiovascular disease. Using gold nanoprobes, the monitoring of the surface plasmon resonance band of the nanoparticles addresses two fundamental issues: how the nanoparticle-homocysteine reaction kinetics are dependent on the concentrations of homocysteine and electrolytes, and how the assembly-disassembly processes are fine-tunable by pH, temperature and particle size. One potential application of the findings is the development of nanoparticle-based colorimetric detection of homocysteine and other thiol-containing amino acids. This method is potentially capable of rapid screening and quantitative determination to target plasma homocysteine levels. |
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General Posters
7:00 PM-9:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Analytical Chemistry |