Synthesis and NMR studies of PLGA copolymers prepared with sequence and stereochemical control

POLY 492

Ryan M. Stayshich, rms34@pitt.edu, Krishnan Damodaran, and Tara Y. Meyer, tmeyer@pitt.edu. Department of Chemistry, University of Pittsburgh, Pittsburgh, PA 15260
Microstructural control of sequence and stereochemistry can be used to improve the material properties of polymers. Although extensive studies of PLA and PLGA have been reported, the complex relationship of sequence and stereochemistry to the properties of these polymers is still not completely understood. We have developed a synthetic method to systematically vary stereochemistry and sequence in PLGA copolymers. A series of dimeric and trimeric units of lactic and glycolic acid were synthesized. These units were then polymerized to yield PLGA copolymers that retained the original oligomer sequence and stereochemistry. Microstructural analysis was performed using high resolution 1H and 13C NMR spectroscopy.
 

Polymers from Renewable Resources
6:00 PM-8:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Polymer Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007