Development of a new class of pyranodithiolene ligands and their metal complexes en route to molybdenum cofactor

INOR 612

Partha Basu, basu@duq.edu1, Barbara Serli-Mitasev2, and Bernd Hammann1. (1) Dept of Chemistry and Biochemistry, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, (2) Dept of Chemistry and Biochemistry, Duquesne Univeristy, 600 Forbes Ave, Pittsburgh, PA 15282
One of the key features of mononuclear molybdenum enzymes is that they are coordinated by a distinct and unique ene-dithiolene ligand, where the ene-dithiolene unit is fused with a pyran ring. The pyran ring itself is linked with a pyrazine ring followed by a pyrimidine ring. These basic units comprise the pyranopterin cofactor. The cofactor is yet to be isolated from a protein and complete synthesis of the cofactor remains challenging. Here we describe our efforts to synthesize the essential components of the cofactor i.e., pyran functionality, ene dithiolene unit. We describe not only the synthesis and characterization of the ligand but also their metal complexes
 

Inorganic Modeling of Biological Systems
7:00 PM-10:00 PM, Tuesday, August 21, 2007 BCEC -- Exhibit Hall - B2, Poster

Sci-Mix
8:00 PM-10:00 PM, Monday, August 20, 2007 BCEC -- Exhibit Hall - B2, Sci-Mix

Division of Inorganic Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007