Putting perfluoropolyethers to work

POLY 73

Jason P. Rolland, jason.rolland@liquidia.com, Liquidia Technologies, 627 Davis Dr, Suite 500, Morrisville, NC 27560 and Joseph M. DeSimone, desimone@unc.edu, Departments of Chemistry and Pharmacology, University of North Carolina at Chapel Hill, Department of Chemical Engineering, North Carolina State University, CB #3290 257 Caudill Laboratories, Chapel Hill, NC 27599.
The use of perfluoropolyethers (PFPEs) for novel applications is explored. PFPEs are low viscosity, highly fluorinated oils with incredibly low surface energies. Direct polymerization of functional PFPEs results in elastomeric, low surface energy materials. PFPE molds show superior properties compared to poly(dimethyl siloxane) and rigid materials in nano-patterning and other applications. A versatile nanofabrication method, Particle Replication In Non-wetting Templates (PRINTTM) allows for the fabrication of particles having absolute control over size, shape and composition. When liquid precursors are introduced to a patterned PFPE mold, isolated particles having designed shape and size can be generated. Harvested, mono-disperse particles having a range of shapes and sizes were fabricated in sizes down to 200 nm out of a wide variety of materials. PRINT particles are shown to be useful in several applications including nano-medicine. Finally, PFPE materials were used to fabricate novel elastomeric solvent-compatible microfluidic devices useful in chemical synthesis.