Drug delivery with polymeric nanoparticles through cell surface tags

PMSE 195

Yasuhiko Iwasaki, yasu.org@tmd.ac.jp1, Haruki Maie2, and Kazunari Akiyoshi, akiyoshi.org@tmd.ac.jp2. (1) Faculty of Chemistry, Materials and Bioengineering, Kansai University, 3-3-35, Yamate, Suita, Osaka, 564-8680, Japan, (2) Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University, Tokyo, 101-0062, Japan
Carbohydrates on the cell surface contribute most communications between cell and its environment, and it may be possible to design the material that interacts with the specific cells and the biological molecules. In this research, 2-methacryloyloxyethyl phosphorylcholine (MPC) polymer nanoparticles which can react with the carbohydrates of the specific cell is newly prepared to achieve novel drug carrier that interact with the specific cell. A water-soluble MPC polymer (PMBH) baring hydrazide groups was synthesized. The MPC polymer showed amphiphilic nature and worked as an emulsifier to make nanoparticles. The unnatural carbohydrates levrinoyl sialic acid (SiaLev) residues on human cervical carcinoma cells (HeLa) cell surface was presented by treated with levrinoyl mannosamine (ManLev). When the PMBH nanoparticles were in contact with levrinoyl mannosamine (ManLev)-treated HeLa cells, they were accumulated in the cells. However, the nanoparticles were not observed in native HeLa cells .
 

Beyond Biocompatibility: Characterization of Functional Biomaterials
1:30 PM-5:25 PM, Tuesday, August 21, 2007 Westin Boston Waterfront -- Grand Ballroom D, Oral

Division of Polymeric Materials: Science & Engineering

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007