MEDI 100 |
| Magnetic resonance imaging (MRI), a non-invasive and high resolution imaging technique has become a powerful tool in diagnostic medicine. The development of the adequate synthetic bifunctional chelates that can hold contrast enhancing metal while being conjugated to a targeting moiety is a critical step for disease-specific MRI. The bifunctional versions of the promising Gd(IIII) chelate, NETA, C-NETA and C-NE3TA have been synthesized and conjugated to a liver targeting moiety, bile acid. The bile acid-ligand conjugates after being complexed with gadolinium(III) have been evaluated for their T1 relaxivities, cellular uptakes, MRI, and fluorescence imaging. The synthesis and in vitro evaluation of Gd(III) based bile acid conjugates as dual MR and flurorescence imaging agents will be reported. |
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Poster Session
7:00 PM-9:00 PM, Sunday, August 19, 2007 BCEC -- Exhibit Hall - B2, Poster
Division of Medicinal Chemistry |