Synthesis and evaluation of novel bifunctional ligands for antibody targeted radiation cancer therapy and MRI

MEDI 347

Hyuna Song, hsong12@iit.edu, Chemistry Division, Department of Biological, Chemical, Physical Sciences, Illinois Institute of Technology, 3101 S. Dearborn St, LS 182, Chicago, IL 60616 and Hyun-Soon Chong, Chemistry Division, Biological, Chemical, and Physical Sciences Department, Illinois Institute of Technology, 3101 S. Dearborn St, LS 182, Chicago, IL 60616.
We previously reported the synthesis and biological evaluation of the structually new bifunctional ligand, C-NETA possessing both a macrocyclic cavity and an acyclic pendant binding group for use in MRI and RIT. C-NETA analogues having longer alkyl spacer have been synthesized, characterized, and evaluated for T1 relaxivities, MRI, and complexation kinetics and stability. We will present synthesis and chemical and biological evaluation of the new bifunctional ligands in this paper.
 

Poster Session
7:00 PM-9:00 PM, Wednesday, August 22, 2007 BCEC -- Exhibit Hall - B2, Poster

Division of Medicinal Chemistry

The 234th ACS National Meeting, Boston, MA, August 19-23, 2007